However, some species of enterobacter, such as enterobacter sakazakii, are opportunistic human pathogens. Prospective, observational study of consecutive patients with enterobacter bacteremia. Enterobacter sakazakii is an opportunistic pathogen that can cause infections such as necrotizing enterocolitis, bacteraemia, meningitis and brain abscesslesions. Enterobacter is the genus name of a group of bacteria consisting of between 12 and 14 species that are known to potentially cause disease in humans, although other enterobacter species sp certainly exist in the environment without causing any known infections in any other organism. In general, the strains from environmental sources grow better at 2030 degrees c. Enterobacter gergoviae adaptation to preservatives commonly used in cosmetic industry. Carbapenems versus alternative antibiotics for the treatment.
Cefepime vs other antibacterial agents for the treatment of. The microbiologic culture monitoring system of sterile body fluids revealed on an episode of enterobacter cloacae and enterobacter amnigenus in blood culture results on the same day. Oct 17, 2014 data from voluntary surveillance of enterobacter spp. Cefepime vs other antibacterial agents for the treatment. Risk factors for relapse or persistence of bacteraemia. Despite the apparent success of several new cephalosporins in the treatment of gramnegative bacterial meningitis, four treatment failures with cefotaxime or latamoxef were encountered two caused by enterobacter and two by serratia spp. The device allows a small amount of sample to be distributed in an. Functional annotation of genes carried by these predicted gis are shown in supplementary file s1. A number of 126 patients with enterobacter bacteremia in 19952004 at the medical. For full access to this pdf, sign in to an existing account, or purchase an annual subscription.
Enterobacter spp were identified and speciated using standard protocols. This work and the related pdf file are licensed under a creative commons attribution 4. Enterobacter article about enterobacter by the free. First report of an enterobacter ludwigii isolate coharboring. Two isolates of mulberrypathogenic bacteria isolated from diseased mulberry roots were investigated in a polyphasic taxonomic study. Infection of hospital patients, notably of the urinary tract, occurs. Enterobacter aerogenes an overview sciencedirect topics. Enterobacter nimipressuralis as a cause of pseudobacteremia. Novel antibiotics effective against grampositive and. Here we sequenced 97 clinical enterobacter species isolates that were both carbapenem susceptible and resistant from various geographic regions to decipher the molecular origins of carbapenem resistance and to understand the changing phylogeny. Background of enterobacter species enterobacter species, particularly enterobacter cloacae and enterobacter aerogenes, are important nosocomial pathogens responsible for various infections, including bacteremia, lower respiratory tract infections, skin and softtissue infections, urinary tract. When the species was defined in 1980, 15 biogroups were described and it was suggested that these could represent multiple species. Voluntary surveillance of bacteraemia due to klebsiella spp. Bo zhu 1, miaomiao lou 1, guanlin xie 1, guofen wang 1, qin zhou 2, fang wang 1, yuan fang 1, ting su 1, bin li 1, yongpin duan 3.
Enterobacter identification charts free pdf ebooks. Bermudez, betalactam antibiotic resistance among enterobacter spp. Knowledge regarding the genomic structure of enterobacter spp. Quantitative comparison in vitro of mutational antibiotic. The amplification of asnuint and asnvint regions linking two other asn trna genes with the integrase gene gave no product. Kubiak 0 2 nour baghdady 2 mary jane ferraro 1 0 david c. Frequency of isolation of enterobacter species from a variety of clinical specimens in a teaching hospital in nigeria raphael m mordi and peter g hugbo microbiology department, western delta university, oghara, delta state, nigeria.
Jun 18, 2019 enterobacter infections can include bacteremia, lower respiratory tract infections, skin and softtissue infections, urinary tract infections utis, endocarditis, intraabdominal infections, septic arthritis, osteomyelitis, cns infections, and ophthalmic infections. Enterobacter is a genus of common gramnegative, facultatively anaerobic, rodshaped, nonsporeforming bacteria of the family enterobacteriaceae. After growth in blood or on agar plates has been confirmed, the bacterial colonies are identified through various, usually automated, methods. Marty 0 0 division of infectious diseases 1 department of pathology, massachusetts general hospital, boston, usa 2 department of. A recent study has shown that the presence of enterobacter cloacae b29 in the gut of a morbidly obese individual may have contributed to the patients obesity. Risk factors for relapse or persistence of bacteraemia caused by enterobacter spp a casecontrol study. Enterobacter article about enterobacter by the free dictionary.
Enterobacter is a gramnegative bacillus that belongs to the enterobacteriaceae family. What additional factors predict microbiological failure in enterobacter bacteraemia is unclear. Colonial morphology differs greatly among enterobacter spp. Enterobacter can be found on human skin and plants as well as in soil, water, sewage, intestinal tracts of humans and animals, and some dairy products health canada. Escherichia coli live in the human gut and are usually harmless but some are pathogenic causing diarrhea and other symptoms as a result of ingestion of contaminated food or water.
Frontiers virulence and antibiotic resistance profiles. As melatonin is secreted from the gut lining, it can cause an increase in enterobacter aerogenes. Enterobacter definition of enterobacter by medical. Acinetobacter baumannii, pseudomonas aeruginosa, and enterobacter spp. This bacterial genus presents particular challenges for the selection of optimal therapy due to the presence of chromosomally encoded ampc betalactamase enzymes. Organisms are widely distributed in nature and occur in the intestinal tracts of humans and animals. Klebsiella, enterobacter, proteus and other enterobacteria. The dramatic increase in antibiotic resistance makes infectious diseases a challenge for medicine worldwide. This file may not be suitable for users of assistive. Betalactam antibiotic resistance among enterobacter spp. Current and historical conditions indexed list of current and historical nationally notifiable conditions. He has an active research group in the area of enterobacter sakazakii. Downloaded from enterobacter cloacae strain isolated.
Enterobacter aerogenes and enterobacter cloacae are gramnegative bacteria that belong to the family enterobacteriaceae. Yersiniabactin and other siderophores produced by clinical. Ec1enterobacter cloacae complex ec2enterobacter cloacae subsp cloacae ec3enterobacter cloacae subsp dissolvens identification and characterization of enterobacter spp. Oct 29, 2010 the clinical significance of the enterobacter nimipressuralis as human pathogens remains unclear. We found multiple retail seafood samples containing enterobacter spp. Enterobacter infections can necessitate prolonged hospitalization, multiple and varied imaging studies and. In particular, enterobacter cloacae complex ecc are common nosocomial pathogens capable of producing a wide variety of infections, such. Jan 21, 2017 the annual incidence of bacteraemia caused by enterobacter spp.
Cid cefepime vs other antibacterial agents for the treatment of enterobacter species bacteremia mark j. This may not be the complete list of references from this article. Frequency of isolation of enterobacter species from a. To study the effect of previously administered antibiotics on the antibiotic susceptibility profile of enterobacter, the factors affecting mortality, and the emergence of antibiotic resistance during therapy for enterobacter bacteremia. Enterobacter definition of enterobacter by medical dictionary. Heteroresistant subpopulations were detected in eight of eight isolates tested, with greater percentages in isolates with uninterpretable mics. Pantoea agglomerans, formerly known as enterobacter agglomerans, is also a common isolate and is grouped with the enterobacter spp. He has an active research group in the area of enterobacter sakazakii cronobacter spp. Enterobacter species are motile aerobic gram negative bacilli belonging to the family enterobacteriaceae. Pdf enterobacter aerogenes and enterobacter cloacae. They are frequently a cause of nosocomial infections.
Risk factors for relapse or persistence of bacteraemia caused. Studies have found specific bacteria such as enterobacter aerogenes are sensitive to melatonin rhythms. Enterobacter species infectious disease and antimicrobial. Three species of enterobacterenterobacter cloacae, enterobacter aerogenes, and enterobacter sakazakiiare responsible for the vast majority of enterobacter infections of humans. The clinical significance of the enterobacter nimipressuralis as human pathogens remains unclear. Carbapenems versus alternative antibiotics for the treatment of bloodstream infections caused by enterobacter, citrobacter or serratia species. Other members of this family include klebsiella, escherichia, citrobacter, serratia, salmonella, and shigella species, among many others. Comprehensive genome analysis of carbapenemaseproducing. Comparative 16s rrna gene sequence analysis combined with rpob gene sequence analysis allocated strains r182t and r33 to the genus enterobacter, with enterobacter asburiae, e.
Cefepime vs other antibacterial agents for the treatment of enterobacter species bacteremia. Stanford deescalation guide for gramnegative bacteremia. Apr 17, 2007 enterobacter sakazakii is an opportunistic pathogen that can cause infections such as necrotizing enterocolitis, bacteraemia, meningitis and brain abscesslesions. Several strains of these bacteria are pathogenic and cause opportunistic infections in immunocompromised usually hospitalized hosts and in those who are on mechanical ventilation. This study analysed cronobacter sakazakii and enterobacter spp. Enterobacter species grow rapidly on selective ie, macconkey and nonselective ie, sheep blood agars. It is the type genus of the order enterobacterales. Data from voluntary surveillance of enterobacter spp. They first achieved wide notoriety as pathogens in 1976 following a nationwide outbreak of septicemia in 378 patients at 25 hospitals resulting from contaminated. Enterobacter spp pathogens poised to flourish at the. This finding suggests that, for humans, the source of carbapenemaseproducing enterobacter spp.
Previous studies have demonstrated a risk of relapsed bacteraemia following therapy with third generation cephalosporins 3gcs. Integrating multiple genomic technologies to investigate. Frontiers multidrugresistant enterobacter cloacae complex. Selected references these references are in pubmed. In the present study, out of 250 isolates studied, 4 54% are li, and are the predominant isolates, followed by klebsiella spp which are about 8032% cases and 8 3. Carbapenems versus alternative antibiotics for the. In this study the taxonomic relationship of strains described as e. Isolated from infection in animals abstract fulltext html download as pdf size. Voluntary surveillance of bacteraemia klebsiella spp. Enterobacter, nosocomial infection authorstream presentation.
Enterobacter, escherichia, hafnia, morganella, providencia and serratia. Pdf file of supplementary figure and tables297 kb pdf. She was treated with intravenous cefotaxime and amikacin postoperatively. Full text the full text of this article is available as a pdf 244k. Enterobacter spp pathogens poised to flourish at the turn.
In the present study, we report a case of enterobacter ludwigii infection in a 17yearold female who underwent surgery for an aneurysmal bone cyst in her left distal femur. Voluntary surveillance of bacteraemia caused by enterobacter spp. Treatment failures of cefotaxime and latamoxef in meningitis. This is the first report showing the role of active efflux in the parabens resistance in e. Enterobacter in the human microbiota is a pathogenic diseasecausing organism or is capable of becoming pathogenic. In the laboratory, growth of enterobacter isolates is expected to be detectable in 24 hours or less. Kpcproducing enterobacter aerogenes infection article pdf available in the brazilian journal of infectious diseases. The full text of this article is available as a pdf 244k. Comprehensive genome analysis of carbapenemaseproducing enterobacter spp new insights into phylogeny, population structure, and resistance mechanisms. Reduction of the bacterial load within the patients gut, from 35% e. Biochemical characteristics and identification of enterobacteriaceae.
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